|
T10174 |
5-R-Rivaroxaban
|
|
Factor Xa
|
|
5-R-Rivaroxaban is (R)-enantiomer of Rivaroxaban. Rivaroxaban (BAY 59-7939) is a highly potent and selective, direct Factor Xa (FXa) inhibitor (IC50 0.7 nM; Ki 0.4 nM). |
|
T4980 |
Betrixaban maleate
|
|
Factor Xa
|
|
Betrixaban maleate is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa. |
|
T1736 |
Apixaban
|
BMS-562247-01 |
Factor Xa
|
|
Apixaban (BMS-562247-01) is an orally active inhibitor of coagulation factor Xa with anticoagulant activity. Apixaban directly inhibits factor Xa, thereby interfering with the conversion of prothrombin to thrombin and pr... |
|
T1184 |
Rivaroxaban
|
BAY 59-7939 |
Factor Xa
,
Thrombin
|
|
Rivaroxaban (BAY 59-7939) is an orally bioavailable oxazolidinone derivative and direct inhibitor of the coagulation factor Xa with anticoagulant activity. Upon oral administration, rivaroxaban selectively binds to both ... |
|
T0372 |
Gabexate mesylate
|
FOY |
Factor Xa
,
Serine Protease
,
Proteasome
|
|
Gabexate mesylate (FOY) is a serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and as a regional anticoagulant for hemodialysis. The drug inh... |
|
T4341 |
Betrixaban
|
PRT054021 |
Factor Xa
|
|
Betrixaban (PRT054021) is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa [1]. It was selected among all lead compounds due to its low hERG channel ... |
|
T8362 |
Benzamidine hydrochloride
|
Benzamidine HCl |
Serine/threonin kinase
,
Serine Protease
|
|
Benzamidine hydrochloride (Benzamidine HCl) is a reversible inhibitor of serine proteases, including trypsin, plasmin, and thrombin (Ki of 35, 350, and 220 μM, respectively). |
|
T22323 |
Enoxaparin sodium
|
|
Thrombin
|
|
Enoxaparin sodium is a low-molecular-weight heparin (LMWH) that has recently been approved by the US FDA for use in patients with medically managed ST-segment myocardial infarction (STEMI), or STEMI with subsequent percu... |
|
T31206 |
Darexaban
|
YM 150,Darexaban, Tanexaban,YM150 |
Factor Xa
|
|
Darexaban (Tanexaban, YM-150) is a direct inhibitor of Factor Xa.Darexaban and Darexaban glucuronide selectively and competitively inhibit FXA and inhibit prothrombin activity at the site of blood clot (thrombus) formati... |
|
T4076 |
Fondaparinux sodium
|
Natural heparin pentasaccharide Sodium,Fondaparin sodium,SR-90107A,Arixtra |
Factor Xa
|
|
Fondaparinux sodium (SR-90107A) is an antithrombin-dependent factor Xa inhibitor with antithrombotic activity. |
|
T2368 |
Edoxaban Tosylate Monohydrate
|
DU-176b,DU-176b tosylate Monohydrate,Lixiana,Edoxaban |
Factor Xa
,
Thrombin
|
|
Edoxaban(DU-176) is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention. |
|
T67853 |
Rivaroxaban Impurity
|
Rivaroxaban-10 |
Factor Xa
|
|
Rivaroxaban Impurity (Rivaroxaban-10) is a potent Blood-coagulation factor Xa inhibitor, IC50= 66 nM. |
|
T31668 |
Eribaxaban
|
PD 348292,PD0348292,PD-0348292,PD-348292,PD 0348292,PD348292 |
Factor Xa
|
|
Eribaxaban (PD348292) is an orally available factor Xa inhibitor for the prevention and treatment of venous thromboembolism. |
|
T20454 |
4-Chlorophenylurea
|
NSC12971,NSC 12971,NSC-12971 |
Factor Xa
|
|
4-Chlorophenylurea (NSC-12971) is a novel orally bioavailable inhibitor of factor Xa. |
|
T27920 |
LY 517717
|
LY-517717,LY517717 |
Factor Xa
|
|
LY 517717 is an orally active inhibitor of coagulation factor Xa with antithrombotic activity for the study of venous thromboembolism (VTE). |
|
T27257 |
EMD-503982
|
EMD503982,EMD 503982 |
Factor Xa
|
|
EMD-503982 is a potential Factor Xa and Factor VIIa inhibitor with potential anticancer and antitumor activity for the study of thromboembolic and neurological disorders. |
|
T27318 |
Fidexaban
|
CI-1031,BX-807834,PD-200022,CI1031,BX807834,ZK-807834 |
Factor Xa
|
|
Fidexaban (CI1031) is a novel, potent, selective and orally active factor Xa inhibitor that has demonstrated antithrombotic activity in a variety of assays |
|
T4690 |
Betrixaban hydrochloride(330942-05-7(free base))
|
PRT054021 hydrochloride |
Factor Xa
|
|
Betrixaban hydrochloride(330942-05-7(free base)) (PRT054021 hydrochloride) is a potent, selective, and orally efficacious factor Xa (fXa) inhibitor (IC50: 1.5 nM). |
|
T78215 |
Dechloro Rivaroxaban
|
|
Factor Xa
,
Others
|
|
Dechloro Rivaroxaban is an orally active and highly selective Factor Xa inhibitor.Dechloro Rivaroxaban has a significant inhibitory effect on free FXa in humans.Dechloro Rivaroxaban also has an inhibitory effect on throm... |
|
T29215 |
Zifaxaban
|
TY 602,TY602,TY-602 |
Factor Xa
|
|
Zifaxaban (TY-602) is an orally active, competitive and selective inhibitor of factor Xa (FXa) with an IC50 of 11.1 nM for human FXa.Zifaxaban has a very high affinity, more than 10,000-fold higher than that of other ser... |
|
T68092 |
Letaxaban
|
TAK-442 |
Factor Xa
|
|
Letaxaban (TAK-442) is a small molecule Xa factor inhibitor that can be used to study polar coronary syndromes and thrombotic blockages. |
|
T66256 |
Ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate
|
|
Factor Xa
|
|
Ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate has an inhibitory effect on coagulation factor Xa, and it can be used in the study of thrombop... |
|
T2368L |
Edoxaban
|
Lixiana |
Factor Xa
,
Thrombin
|
|
Edoxaban (Lixiana) (DU-176) is a selective, potent and orally active factor Xa (FXa) inhibitor with K i s of 0.561 nM and 2.98 nM for free FXa and prothrombinase, respectively. Edoxaban is an anticoagulant agent and is a... |
|
T26793 |
BI-11634
|
|
|
|
BI-11634 is a factor Xa inhibitor. |
|
T35926 |
Bz-IEGR-pNA (acetate)
|
|
|
|
Bz-IEGR-pNA is a colorimetric substrate for Factor Xa.1 Factor Xa preferentially binds to and cleaves the Ile-Glu-Gly-Arg (IEGR) peptide sequence to release p-nitroanilide (pNA), which can be quantified by colorimetric d... |
|
T23755 |
AS1468240
|
AS 1468240,AS-1468240 |
|
|
AS1468240 is a factor Xa inhibitor. It has significant oral anticoagulant activity. |
|
T69276 |
KFA1982
|
|
|
|
KFA1982 is a novel and potent factor Xa inhibitor. |
|
T27202 |
DPC-423
|
DPC-423 Free |
|
|
DPC-423 is a factor Xa inhibitor potentially for the treatment of thrombosis. |
|
T28921 |
Tanogitran
|
BIBT 986,BIBT986,BIBT-986 |
|
|
Tanogitran, a coagulation factor Xa inhibitor, is used potentially for the treatment of septic shock. |
|
T27698 |
JTV-803 mesylate
|
JTV803,JTV 803,JTV-803 |
|
|
JTV-803 is a factor Xa inhibitor. JTV-803 showed a competitive inhibitory effect on human factor Xa, with a K(i) value of 0.019 microM and IC(50) value of 0.081 microM. JTV-803 was 100 times more selective in inhibiting ... |
|
T27224 |
DX-9065A HCl hydrate
|
DX9065,DX 9065,DX9065A,DX 9065A,DX-9065A,DX-9065 |
|
|
DX-9065A is a factor Xa inhibitor. DX-9065a inhibits proinflammatory events induced by factor Xa and gingipains. DX-9065a is a competitive inhibitor of the Spectrozyme FXa (SpFXa) cleavage by both fXa and prothrombinase ... |
|
T37054 |
Z-D-Arg-Gly-Arg-pNA . 2 HCl
|
|
|
|
Z-RGR-pNA is a chromogenic substrate for the determination of factor Xa. |
|
T21037 |
Edoxaban Isomer
|
|
|
|
Edoxaban Isomer is an impurity of Edoxaban, which is a novel inhibitor of factor Xa. |
|
T70349 |
DJT06001
|
|
|
|
DJT06001 is a selective Factor Xa inhibitor, reducing thrombus formation with low risk of bleeding. |
|
T70536 |
Idraparinux Na
|
|
|
|
Idraparinux Na is an Antithrombotic, Indirect, Selective, Synthetic Factor Xa Inhibitor |
|
T38795 |
Suc-Ile-Glu(γ-pip)-Gly-Arg-pNA hydrochloride
|
|
|
|
Suc-Ile-Glu(γ-pip)-Gly-Arg-pNA hydrochloride is a chromogenic substrate specifically designed for factor Xa. |
|
T12782 |
RWJ-445167
|
3DP-10017 |
Factor Xa
,
Thrombin
|
|
RWJ-445167 is a thrombin and factor Xa dual inhibitor(Ki of 4.0 nM and 230 nM, respectively), with potent antithrombotic activity. |
|
T28491 |
R-1663
|
R1663 |
|
|
R-1663 is a factor Xa inhibitor. R-1663 prolonged clotting times, inhibited thrombin generation (peak height and endogenous thrombin potential [ETP]) and anti-factor Xa activity in a concentration-dependent manner withou... |
|
T71096 |
GCC-4401C methanesulfonate
|
|
|
|
GCC-4401C methanesulfonate is a factor Xa inhibitor similar to rivaroxaban that is currently under development for venous thromboembolic disease (VTE). |
|
TP1129 |
Boc-Ile-Glu-Gly-Arg-AMC
|
IEGR-AMC |
|
|
Boc-Ile-Glu-Gly-Arg-AMC (IEGR-AMC), a specific, highly fluorogenic substrate for clotting enzyme factor Xa (coagulation factor Xa). Boc-IEGR-AMC is also hydrolyzed by acrosin from the ascidian Halocynthia roretzi. |
|
T12694 |
Razaxaban hydrochloride
|
BMS 561389 hydrochloride,DPC 906 hydrochloride |
Others
|
|
Razaxaban hydrochloride is a highly potent, selective and orally active inhibitor of factor Xa(Ki of 0.19 nM),has strongly antithrombotic activity. |
|
T27121 |
Darexaban glucuronide
|
YM 222714,YM222714,YM-222714 |
|
|
Darexaban glucuronide is the major component in plasma after oral administration of darexaban to humans. Darexaban (YM150) is a direct inhibitor of factor Xa. |
|
T78424 |
CH3OCO-D-CHA-Gly-Arg-pNA acetate
|
|
Factor Xa
|
|
CH3OCO-D-CHA-Gly-Arg-pNA acetate serves as a chromogenic substrate for Factor Xa, as documented in sources [1] [2]. |
|
T70184 |
YM-60828 dihydrochloride
|
|
|
|
YM-60828 dihydrochloride is a Factor Xa (FXa) inhibitor and anticoagulant used in the treatment of venous thromboembolic disease. |
|
T35931 |
GGACK (hydrochloride)
|
|
|
|
GGACK is an inhibitor of urokinase-type plasminogen activator (uPA) and factor Xa (Kis = 1.8 and 8.7 μM, respectively).1,2
1.Kettner, C., and Shaw, E.The susceptibility of urokinase to affinity labeling by peptides of ar... |
|
T71362 |
GCC-4401C free base
|
|
|
|
GCC-4401C free base is a factor Xa inhibitor similar to rivaroxaban that is currently under development for venous thromboembolic disease (VTE). |
|
T10820 |
Ciraparantag
|
PER977 |
Others
|
|
Ciraparantag is an inhibitor of thrombin and factor Xa. Ciraparantag is a broad-spectrum reversal agent for anticoagulants, including unfractionated heparin, low-molecular-weight heparin, and certain direct oral anticoag... |
|
T27514 |
GW-813893
|
GW813893,GW 813893,GSK813893,GSK-813893,GSK 813893 |
|
|
GW-813893 is a potent, selective and orally active factor Xa inhibitor. GW813893 inhibited FXa and prothrombinase activity with a Ki of 4.0 nM and 9.7 nM, respectively. |
|
T71429 |
O-Demethyl apixaban sulfate
|
|
|
|
O-Demethyl apixaban sulfate is a metabolite of Apixaban, a potent and highly selective factor Xa inhibitor. Apixaban is currently under development for treatment of arterial and venous thrombotic diseases. |
|
T29190 |
YM-75466
|
YM 466,YM-466,YM75466,YM 75466,YM-75466 Free |
|
|
YM-75466 is a factor Xa inhibitor. YM-75466 did not prolong coagulation time even at the dose which exerted significant antithrombotic effects, while it decreased TAT level in plasma in a dose-dependent manner. |
